Raspberry ketones

What Is Raspberry Ketone and How Does It Work?

There are 200 chemicals in a raspberry that contribute to its characteristic raspberry flavor. Raspberry ketone, for example, was once singled out by food makers for its powerful odor. Raspberry ketone is likely used in today's berry-flavored sweets, soaps, and candles. The raspberry ketone has recently resurfaced in the media, this time as a putative weight-loss tool.

Raspberry ketone can be found in cranberries, blackberries, and red raspberries, all of which belong to the Rosaceae Rubus idaeus L. family. Europe, Northern Africa, and Central Asia are home to red raspberries. Beta-carotene and vitamins A, E, and C are among the vital components found in them. Because raspberry ketone is only found in trace amounts in the fruit, berry-flavored goods often employ raspberry ketone synthesized in a lab.

Around 2010, scientists realized that raspberry ketone had a molecular structure that was similar to capsaicin, the molecule that gives chili peppers their heat. Capsaicin may also help to reduce weight gain, according to preliminary research. In light of these findings, scientists tested raspberry ketone on mice and human tissue to determine if it affects weight gain as well.


Is raspberry ketone effective?

"There is presently no reliable study on the use of raspberry ketone in people for any health problem. There is a need for more high-quality research "Catherine Ulbricht, a senior pharmacist at Massachusetts General Hospital in Boston and co-founder of Natural Standard Research Collaboration, a group that evaluates data on herbs and supplements, agreed.

Only a few exploratory studies on raspberry ketone as a weight reduction aid have been conducted, and none of them have been conducted in humans. However, research on mice or cells have indicated that there may be a weight-loss impact. According to a report published in the journal Life Sciences in 2005, raspberry ketone inhibited weight gain in the liver and visceral fat ("belly fat") that surrounds organs in mice fed a high-fat diet. Another study found that raspberry ketone accelerated lipid (fat molecule) breakdown within fat cells. Raspberry ketone also caused fat cells to secrete more of the protein adiponectin, according to a 2010 study published in Planta Medica. Obese people and people with type 2 diabetes have lower levels of adiponectin in their bodies. Mice fed a high-fat diet with raspberry ketone and ellagic acid, another chemical found in raspberries, acquired less weight, according to a 2016 study presented at the Experimental Biology conference. The researchers also discovered that raspberry ketone changed the expression of genes in the mice's liver in a way that looked to be beneficial to their health.

However, according to a 2017 study conducted by Danish experts, raspberry ketone may not lower body fat levels on its own. Researchers discovered that mice fed a high-fat diet with raspberry ketone acquired less weight than mice who were not given raspberry ketone in that study, which was published in the journal Food & Function. However, the raspberry ketone-fed mice ate less food than the control mice, leading the researchers to infer that raspberry ketone had no effect on fat levels beyond what would be expected from a lower-calorie diet. According to preliminary study, raspberry ketone can help fight indications of aging when applied directly to the skin. According to a 2008 study published in the journal Development Hormone & IGF Research, raspberry ketone treatments increased both skin elasticity and hair growth over the course of five months in 15 participants.


More study is frequently sparked by findings in mice and cells developing on lab pans. Doctors, on the other hand, look for many human studies of a chemical with a large number of volunteers in order to get reliable results. The weight loss evidence on raspberry ketone is deemed "insufficient" by the US Department of Defense Human Performance Resource Center. Raspberry ketone received a "C" from the Natural Standard Research Collaboration for evidence supporting claims for any health benefit.


Is raspberry ketone a safe supplement?

Raspberry ketones were initially classified as a "Generally Recognized as Safe" (GRAS) food additive by the US Food and Drug Administration in the 1960s. However, GRAS certification is only granted if a person consumes fewer than two milligrams of raspberry ketone per day. The majority of weight reduction supplements include significantly more raspberry ketone. At supplement dosages ranging from 50 to 250 mg per serving, raspberry ketone hasn't been thoroughly researched. There are also some recognized adverse effects associated with their use.

Ulbricht stated, "Raspberry ketone may lower blood sugar levels and reduce the risk of bleeding." As a result, persons using diabetes medications should have their health care team keep a careful eye on them. Changes in body fat and weight, changes in inflammation, heart palpitations, and shakiness are all possible side effects of raspberry ketone. Raspberry ketone may interfere with medications that control heart rate and cholesterol, as well as hormones.

"Raspberry ketone use in humans is still lacking in credible safety information," Ulbricht stated.

Researchers in Denmark utilized a model to look at the potential effects of raspberry ketone on the human body in a 2015 study published in the journal Regulatory Toxicology and Pharmacology. Their findings revealed that raspberry ketone could have potentially harmful effects on the heart and reproductive system. "Further experimental studies are needed to clarify the compound's hazardous potential," the researchers stated.